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Nucleoside Triphosphates and their Analogs: Chemistry, Biotechnology, and Biological ApplicationsFrom CRC Press
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Used extensively in cellular and molecular biology research and cytogenetic applications, nucleotide analogs are currently available for the treatment of various diseases. Nucleoside Triphosphate and Their Analogs: Chemistry, Biotechnology, and Biological Applications features the contributions of 18 scientists from both academia and industry in the first complete source dedicated entirely to nucleoside triphosphate (NTP). The text provides collective information on the chemical, physiochemical, and biological properties of both natural and modified NTP alongside their application in life sciences.
This book examines the structural components of NTPs' diverse biological properties and therapeutic consequences, including cytotoxic compounds, antiviral agents, and immunosuppressive molecules. The text describes synthetic methods used for all types of nucleotides and reviews families of enzymes that depend on nucleotides for assembling DNA and RNA molecules. This book also emphasizes the key role NTP plays in the global tracking of conformational changes in nucleic acids and nucleic acid complexes and the investigation of cellular processes and genetic material. The author details the pharmaceutical and diagnostic applications of NTP modification and how fluorescent labeled nucleotide analogs provide sensitive probes for studying the structure, dynamics, and interactions of nucleic acids.
Nucleoside Triphosphate and Their Analogs: Chemistry, Biotechnology, and Biological Applications discusses the potential of current applications and future research into context with an in-depth analysis of the role anticancer and antiviral nucleoside analogs play in medical treatments, including antiretroviral therapy regimens (for the treatment of HIV), anti-rejection therapy for organ transplants, hematological malignancy therapy, and the treatment of nonmalignant disorders, solid tumors, immunologic diseases, and multiple sclerosis.
- Sales Rank: #1971401 in Books
- Published on: 2005-04-26
- Original language: English
- Number of items: 1
- Dimensions: 9.32" h x .97" w x 6.32" l, 1.58 pounds
- Binding: Hardcover
- 408 pages
Review
…the book is a clear success and represents an excellent and valuable treatise on nucleoside triphosphates. It is a must for all active chemists and researchers interested in the field of nucleoside and nucleotide analogues as potential chemotherapeutic agents. It would be a good acquisition for both personal and institutional libraries…
-ChemBioChem, Vol. 7, No. 2, Feb. 2006
Most helpful customer reviews
0 of 0 people found the following review helpful.
Very informative and highly relevant to current biotechnology
By Hongyi Wang
This is a collection of a few chapters written by respective experts in their fields. It is very informative in the synthetic chemistry of modified nucleoside triphosphate (NTP) with large number of synthesis examples and methods. It has also rich description of NTPs' usage in some hot areas of biotechnology and medicinal chemistry, in particular, polymerases, DNA sequencing, and antiviral drugs.
It is an invaluable resource book for those working in this maybe narrow but high-impact biotechnology field.
There are some mislabeled or misplaced reaction schemes and figures.
0 of 0 people found the following review helpful.
Five Stars
By mike jensen
Product as described--thanks!
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